Dr. Martin Haubrock

Groupleader: Gene Regulation

Telephone: 0551-3961784

E-Mail: martin.haubrock@bioinf.med.uni-goettingen.de

Location: Goldschmidtstr. 1, 37077 Göttingen, 
                2. OG, Room: 2.111

ORCID: https://orcid.org/0000-0001-5292-4561

Curriculum Vitae

2021: PhD: Prediction, analysis and significance of characteristic transcription factor binding sites and their potential master control function for the transcriptional gene regulation
since 10.2018: Research assistant and group leader (Group Gene Regulation) at the Institute of Medical Bioinformatics (Head: Prof. Beißbarth) , University Medical Center Göttingen
01.2003-09.2018 Research assistant and lecturer at the Institute of Bioinformatics (Head: Prof. Wingender), University Medical Center Göttingen
06.2000/12.2002 Research and development at Biobase GmbH (Braunschweig/Wolfenbüttel)
02.2000: Diplom (Masters) Thesis: PathFinder: reconstruction and dynamic visualization of metabolic pathways.
1994-2000: Study of Computer Science and Bioinformatics (Faculty of Technology) at the University of Bielefeld
1987-1990: Beisenkamp Gymnasium - Hamm (Westf.), Germany
1981-1987: Realschule Bönen (Secundary School), Germany
Feb. 8, 1971: Born in Unna (Westf.), Germany

Research focus

Analysis and interpretation of gene regulation in eukaryotes

  • Prediction of TFBSs
  • Prediction and analysis of transcriptional networks
  • Modeling of gene regulatory networks
  • Analysis of DNA hypersensitivity assays, immunoprecipitation (IP) of proteins that interact with DNA, modified histones, chromatin remodelling proteins and transcription factors sequencing data
  • Application of machine learning methods to analyze nucleosome positioning, transcription factor binding sites composition in the context of proximal and distal regulatory interactions


Selected Publications

Daou R, Beißbarth T, Wingender E, Gültas M, Haubrock M.:
Constructing temporal regulatory cascades in the context of development and cell differentiation.
PLoS One. 2020 Apr 10;15(4):e0231326. doi: 10.1371/journal.pone.0231326. 

Wingender E., Schoeps T., Haubrock M., Dönitz J.:
TFClass: expanding the classification of human transcription factors to their mammalian orthologs.
Nucleic Acids Res. 2018 Jan. 4;46(D1):D343-D347 doi: 10.1093/nar/gkx987

Haubrock M., Hartmann F., Wingender E.:
NF-Y binding Site Architecture Defines a C-Fos targeted Promoter Class.
PLoS One. 2016 Aug. 12; 11(8):e0160803 doi: 10.1371/journal.pone.0160803

Schirmer M.A., Lüske C.M., Roppel S., Schaudinn A., Zimmer C., Pflüger R., Haubrock M., Rapp J., Güngör C., Bockhorn M., Hackert T., Hank T., Stroebel O., Werner J., Izbicki J.R., Johnsen S.A., Gaedecke J., Brockmöller J., Ghadimi B.M.:
Relevance of Sp Binding Site Polymorphism in WWOX for Treatment Outcome in Pancreatic Cancer.
J. Natl. Cancer Inst. 2016 Feb. 8; 108(5) doi: 10.1093/jnci/djv387

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