From Molecular phenotyping to personalized pharmacotherapy in cardiology

Someone's sitting in a lab doing research

Project Partners

PD Dr. Mahir Karakas (Univerity Medical Center Hamburg-Eppendorf)
Prof. Tanja Zeller (University Medical Center Hamburg-Eppendorf)
Prof. Tim Beißbarth (University Medical Center Göttingen)
Prof. Dr. Massimiliano Caprio (IRCCS San Raffaele, Italy)
Dr. David-Alexandre Tregouet (Institute for Cardiometabolism and Nutrition Pierre & Marie Curie, Paris, France)

Aims of the project

Cardiovascular disease (CVD) represents the most important cause of morbidity and mortality in the EU.
Within the MATCH project an interdisciplinary and translational approach integrating knowledge from comprehensive Omics-based molecular phenotype analyses, cardiovascular epidemiology, imaging, bioinformatics, statistics and molecular biology will be taken.

The overall aim of the MATCH project is the identification of a biomarker signature which associates with beneficial outcome on specific lipid therapy, and ideally is not dynamic under ongoing therapy.

Contribution of the Department of Medical Bioinformatics

Our deparment is involved in the Workpackages 2 and 5:

Work Package WP2: Bioinformatical derivation of molecular biomarker signature
Within MATCH a molecular biomarker signature to discriminate responders to various lipid therapies from non-resonders will be established. based on the comprehensive set of Omics data established by WP1 (Hamburg), the application of bioinformatical, statistical and systems medicine approaches shall derive the best molecular biomarker signature for discrimination. 
Here in Göttingen, we will perform bioinformatical and statistical analyses to derive and validate biomarker signature.

Work Package WP5: Project coordination, management and ELSA
Efficient and effective project management ensures that the project meets the timeline and delivers the anticipated results.
Due to the clinical dimension of MATCH and the use of patient biomaterial and data within this project, ethical, legal and social aspects (ELSA) will be taken care of.

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