The MTB-Report Seminar Series is a joint event of all partners and members of the MTB-Report project. Monthly, members of the different groups as well as invited speakers present their projects.
Unless announced otherwise, the seminar takes place monthly on the fourth Wednesday at 10.30am . Due to the SARS-CoV-2 related measures, the seminar takes place via video conference .
Coordination/Contact: Dr. Jürgen Dönitz
Date: 28th of July 10.30 am
Speaker: Jingyu Yang
Topic: DNA-seq-pipeline for molecular tumor board platform (Onkopus)
Abstract: Next-generation sequencing is empowering precision medical oncology research. Formerly, Our MTB platform (Onkopus) can only accept well-defined CSV format (CNV, SNV, Structural variants) as input. To fill the gap between raw genome sequencing data to annotated variants information. We developed a DNA sequencing analysis pipeline, It covers essential phases for full DNA-seq analyzing procedure, including quality control, alignment, raw bam preprocessing and variant discovery sessions such as SNV calling, CNV calling, and Structural variants detecting. The pipeline holds a dockerized version and can be easily customized and deployed on different systems.
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Press release from the Volkswagenstiftung:
Big Data: 18 Millionen Euro für 16 innovative Projekte in den Lebenswissenschaften
Press release from the UMG:
Molekulares Tumorboard: Zielgerichtet gegen fortgeschrittene Krebserkrankungen vorgehen
Borchert, F., Mock A., ...., Hügel J., et al.
Knowledge bases and software support for variant interpretation in precision oncology
Briefings in Bioinformatics, bbab134, 2021, 1–17
Publications from preliminary work
Perera-Bel J., Leha A., Beißbarth T.
Bioinformatic Methods and Resources for Biomarker Discovery, Validation, Development, and Integration.
In: Badve S., Kumar G. (eds) Predictive Biomarkers in Oncology. Springer, Cham. (2019)
Perera-Bel J, Hutter B, Heining C, Bleckmann A, Fröhlich M, Fröhling S, Glimm H, Brors B, Beißbarth T.
From somatic variants towards precision oncology: Evidence-driven reporting of treatment options in molecular tumor boards.
Genome Med. 2018 Mar 15;10(1):18.
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