The MTB-Report Seminar Series is a joint event of all partners and members of the MTB-Report project. Monthly, members of the different groups as well as invited speakers present their projects.
Unless announced otherwise, the seminar takes place monthly on the fourth Wednesday at 10.30am . Due to the SARS-CoV-2 related measures, the seminar takes place via video conference .
Coordination/Contact: Dr. Jürgen Dönitz
Date: 24 th of November 10.30 am
Speaker: Kevin Kornrumpf (PhD Department of Medical Bioinformatics)
Topic: Copy Number Variations - From medical analysis to a bioinformatics approach.
Abstract: CNVs have a major impact on the development of cancer. However, in
many medical publications, these are analyzed only in the context of individual
cancer entities. A generalized and automated approach to analyze these CNV is
still missing. In this presentation, I will present the current state-of-art
of analysis, our ideas to automate the search for potentially harmful
CNV genes and some existing databases and tools.
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Press release from the UMG:
Molekulares Tumorboard: Zielgerichtet gegen fortgeschrittene Krebserkrankungen vorgehen
Press release from the Volkswagenstiftung:
Big Data: 18 Millionen Euro für 16 innovative Projekte in den Lebenswissenschaften
Schlotzig V, Kornrumpf K, König A, Tucholski T, Hügel J, Overbeck TR, Beissbarth T, Koch R, Dönitz J.
Predicting the Effect of Variants of Unknown Significance in Molecular Tumor Boards with the VUS-Predict Pipeline.
Stud Health Technol Inform. 2021 Sep 21;283:209-216.
Borchert, F., Mock A., ...., Hügel J., et al.
Knowledge bases and software support for variant interpretation in precision oncology
Briefings in Bioinformatics, bbab134, 2021, 1–17
Publications from preliminary work
Perera-Bel J., Leha A., Beißbarth T.
Bioinformatic Methods and Resources for Biomarker Discovery, Validation, Development, and Integration.
In: Badve S., Kumar G. (eds) Predictive Biomarkers in Oncology. Springer, Cham. (2019)
Perera-Bel J, Hutter B, Heining C, Bleckmann A, Fröhlich M, Fröhling S, Glimm H, Brors B, Beißbarth T.
From somatic variants towards precision oncology: Evidence-driven reporting of treatment options in molecular tumor boards.
Genome Med. 2018 Mar 15;10(1):18.
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